Stopping cells from dividing

Stopping cells from dividing

than inhibiting cell division? The quest to identify means to stop cells from proliferating has driven generations of researchers to investigate the mechanisms regulating the cell division cycle. The cell cycle consists of several phases. Progression from one phase to the next depends on the activity of specific proteins. In order to pass the checkpoints between two phases, several classes of p...

Organelle segregation during mitosis: Lessons from asymmetrically dividing cells

Studies on cell division traditionally focus on the mechanisms of chromosome segregation and cytokinesis, yet we know comparatively little about how organelles segregate. Analysis of organelle partitioning in asymmetrically dividing cells has provided insights into the mechanisms through which cells control organelle distribution. Interestingly, these studies have revealed that segregation mech...

Collective dynamics of dividing chemotactic cells.

The large scale behavior of a population of cells that grow and interact through the concentration field of the chemicals they secrete is studied using dynamical renormalization group methods. The combination of the effective long-range chemotactic interaction and lack of number conservation leads to a rich variety of phase behavior in the system, which includes a sharp transition from a phase ...

Dividing Cells as the Prerequisite for Vernalization.

Novel surface antigen expressed on dividing cells but absent from nondividing cells

Radioimmunoprecipitation followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis was used to study the distribution on human lymphoid cells of a previously undescribed surface antigen recognized by several heteroantisera. A glycoprotein with a 90,000 mol wt (under reducing conditions) was detected on all cell lines tested including T, B, null, and myeloid cell lines, although the ...